CELLULAR BIOCHEMISTRY STUDIES ON CHEMICALS SELECTED FOR EVALUATION BY NTP

腹腔注射铬酸钠、铬酸锌钾和 羰基铬对小鼠的遗传毒性作用进行比较 具有潜在骨髓毒性作用的六价盐。 在 在所用剂量下，微核率无显著升高 由三种铬酸盐中的任何一种引起的频率。 的研究 酒石酸锑钾的吸收和靶器官毒性 在给予腹膜内注射7或14周的大鼠和小鼠中完成。 剂量- 相关水平的锑在肝脏、血液、肾脏、脾脏 和心脏，但没有生化变化表明毒性 除了肝脏 肝细胞变性和多灶性肝 变性发生与剂量相关的升高， 肝脏特异性血清酶、山梨醇脱氢酶和 丙氨酸转氨酶 注射部位和天数的改变 的治疗表明，腹腔注射途径实际上可用作 2年研究中的给药途径。 类似的研究 在吸入二茂铁的大鼠和小鼠中进行14或 90天 肺铁负荷与剂量成比例增加， 时间 唯一的毒性反应是亚急性坏死性炎症， 14小时后，两种动物的鼻甲骨中的嗅上皮 给药天数，以及变性、炎症、增生和 给药90天后的化生（仅大鼠）。 研究终止。

I.P. injection studies with sodium chromate, zinc potassium chromate, and chromium carbonyl were conducted on mice to compare the genotoxic effects of the hexavalent salts with their potential myelotoxic effects. At the doses employed, there were no significant elevations of micronucleus frequencies caused by any of the three chromate salts. Studies of the absorption and target organ toxicity of antimony potassium tartrate were completed in rats and mice given i.p. injections for 7 or 14 weeks. Dose- related levels of antimony accumulates in the liver, blood, kidney, spleen, and heart, but there were no biochemical changes indicative of toxicity except in the liver. Hepatocyte degeneration and multifocal liver degeneration occurred in association with dose-related elevations in activities of the liver-specific serum enzymes, sorbitol dehydrogenase and alanine aminotransferase. Alteration of the site of injection and the days of treatment demonstrated that the i.p. route could be practically used as a route of administration in 2-year studies. Similar studies were conducted in rats and mice administered ferrocene by inhalation for 14 or 90 days. Lung burdens of iron were increased in proportion to dose and time. The only toxic response was subacute, necrotizing inflammation of the olfactory epithelium in the nasal turbinates of both species after 14 days administration, and degeneration, inflammation, hyperplasia, and metaplasia (rats only) after 90 days administration. Studies terminated.