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MYELOTOXICITY IN MICE CAUSED BY DRINKING MIXTURE OF GROUNDWATER CONTAMINANTS

MYELOTOXICITY IN MICE CAUSED BY DRINKING MIXTURE OF GROUNDWATER CONTAMINANTS
饮用地下水污染物混合物引起的小鼠骨髓毒性
批准号：
3918652
负责人：
H L HONG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3918652
关键词：
biological models environmental toxicology hematopoiesis hematopoietic stem cells industrial waste laboratory mouse toxin metabolism water pollution

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中文摘要
翻译
关注化学物质对健康的潜在不利影响 受污染的地下水已经存在多年。在 目前的研究是对女性的骨髓参数进行监测 B6C3F1小鼠暴露于饮用水中的化学混合物17 数天或最多32周。这种混合物由25种常见的 有毒废物堆放场附近经常发现地下水污染物， 由环境保护局的调查确定。这些实验的目的是 是为了比较不同时间段的造血功能 并确定残留损伤是否可能 在随后的辐射中表现为造血术 干细胞受损或接近恢复。
英文摘要
Concern over the potential adverse health effects of chemically contaminated groundwater has existed for many years. In the present studies bone marrow parameters were monitored in female B6C3F1 mice exposed to a chemical mixture in drinking water for 17 days or up to 32 weeks. The mixture consisted of 25 common groundwater contaminants frequently found near toxic waste dumps, as determined by EPA surveys. The purpose of these experiments were to compare the hematopoisis among the different time courses of exposure and to determine whether residual damage could be demonstrated by subsequent radiations at a time when hematopoietic stem cells sustained injury or nearly recovered.
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