PSYCHOBIOLOGY AND TREATMENT OF PERI-MENOPAUSAL DISORDERS

围绝经期疾病的心理生物学和治疗

• 批准号: 3881023
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3881023
• 关键词: clinical depression; estrogens; female; follicle stimulating hormone; gonadotropin releasing factor; human subject; human tissue; interview; luteinizing hormone; menopause; neuroendocrine system; psychobiology; psychosomatic disorders; thyrotropin releasing hormone

The goals of this project are to detect and accurately describe peri-menopausal mood disorders, explore their pathophysiology and response to pharmacological and environmental manipulation, and to document the relationship between reproductive endocrine change and disorders of mood as a way of further investigating the neurobiology of psychiatric illness. Findings to date include the following: 1) an absence of differential response to TRH stimulation in menopausal depressed patients compared with menopausal controls; 2) elevation of GnRH stimulated FSH and LH secretion in climacteric patients as a product of age but not the presence of irregular menstrual cycles; 3) preliminary evidence of the efficacy of estrogen in the treatment of climacteric mood disorders without somatic symptomatology.

该项目的目标是检测和准确描述 围绝经期情绪障碍，探讨其病理生理和反应 药理学和环境操纵，并记录 生殖内分泌变化与情绪障碍的关系 一种进一步研究精神疾病的神经生物学的方法。 迄今为止的研究结果包括：1）缺乏差异 绝经期抑郁症患者对TRH刺激的反应， 绝经对照组; 2）GnRH刺激FSH和LH分泌升高 在更年期患者中，这是年龄的产物，而不是 月经周期不规则; 3）疗效的初步证据 雌激素治疗更年期情绪障碍 医学。