LIPID METABOLISM OF THE MACACA FASCICULARIS

食蟹猴的脂质代谢

• 批准号: 4705578
• 负责人: D BARNARD
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4705578
• 关键词: erythrocytes; fatty acids; lipid metabolism; nutrient bioavailability; nutrition related tag

The study will examine the metabolism of exogenous fatty acids by Macaca fascicularis. Trans fatty acids which can not be synthesized by eukaryotes will be used as the exogenous fatty acid marker. Trans fatty acids are geometrical isomers of cis-fatty acids which can be synthesized by eukaryotes. Trans fatty acids are not toxic as long as the essential fatty acid requirements are satisfied. The trans fatty acids are catabolize and removed from the body shortly after they are removed from the diet. Twelve male Macaca fascicularis monkeys will be used in the study. Six of the monkeys will be fed the control diet and the others will be fed the experimental diet containing trans fatty acids. Thirty-six weeks will be required to complete the study. The objectives of the study are to: 1) Determine if the monkeys have the gut flora required to produce trans fatty acids. 2) Determine if trans fatty acids are incorporated into the RBC membrane of the monkeys. 3) Determine if the trans fatty acids incorporated into the RBC membrane effect the membrane function by examining a membrane-bound enzyme.

这项研究将研究猕猴对外源脂肪酸的代谢 束状肌。真核生物不能合成的反式脂肪酸 将其作为外源脂肪酸的标记。反式脂肪酸是 顺式脂肪酸几何异构体的合成 真核生物。反式脂肪酸无毒，只要必需脂肪 满足了酸的要求。反式脂肪酸被分解代谢和 在它们从饮食中移除后不久就被从身体中移除。 这项研究将使用12只雄性短尾猴。其中六个 猴子将被喂以对照饲料，其他猴子将被喂以 含有反式脂肪酸的试验性饮食。三十六周将是 才能完成这项研究。 研究的目的是： 1)确定猴子是否有产生反式反应所需的肠道菌群 脂肪酸。 2)确定反式脂肪酸是否被掺入红细胞膜 猴子们。 3)确定红细胞膜上是否含有反式脂肪酸 通过检测一种膜结合酶来影响膜的功能。