LIPID METABOLISM OF THE MACACA FASCICULARIS

食蟹猴的脂质代谢

• 批准号: 3978277
• 负责人: D BARNARD
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3978277
• 关键词: erythrocyte membrane; erythrocytes; fatty acids; lipid metabolism; nutrient bioavailability; nutrition related tag

The study will examine the metabolism of exogenous fatty acids by Macaca fascicularis. Trans fatty acids which cannot be synthesized by eukaryotes will be used as the exogenous fatty acid marker. These fatty acids are geometrical isomers of cis fatty acids which can be synthesized by eukaryotes. The trans fatty acids are catabolized and removed from the body shortly after the fatty acids are removed from the diet. Twelve male M. fascicularis monkeys are being used in the study. Six will be fed the control diet, and the others will receive the experimental diet. The objectives of the study are to determine if: (1) the monkeys have the gut flora required to produce trans fatty acids, (2) trans fatty acids are incorporated into the RBC membrane of the monkeys, and (3) the linoleate to arachidonate ratio of the erythrocyte membrane is altered.

这项研究将研究猕猴对外源脂肪酸的代谢 束状肌。真核生物不能合成的反式脂肪酸 将其作为外源脂肪酸的标记。这些脂肪酸是 顺式脂肪酸几何异构体的合成 真核生物。反式脂肪酸被分解并从 在脂肪酸从饮食中移除后不久。十二名男性 这项研究中使用了束支原体猴子。六个人将被喂食 控制饮食，其他人将接受实验饮食。这个 这项研究的目的是确定：(1)猴子是否有胆量 产生反式脂肪酸所需的菌群，(2)反式脂肪酸 被掺入猴子的红细胞膜，以及(3)亚油酸酯到 红细胞膜花生四烯酸比值改变。