LIPID METABOLISM OF THE MACACA FASCICULARIS

这项研究将检查外源脂肪酸的新陈代谢 由食蟹猴创作。反式脂肪酸，不能 由真核生物合成的外源脂肪酸将被用作 记号笔。这些脂肪酸是顺式脂肪酸的几何异构体。 可以由真核生物合成的酸。反式脂肪 人体内的酸很快就会分解并排出体外。 脂肪酸会从饮食中去除。12名男性M。 研究中使用的是束猴。六个人被喂食了 对照组喂食，其余组喂以实验饲料。这个 饲喂含0.5%对照饲料的猕猴红细胞膜 脂肪酸的反式十八酸异构体。审查 这些猴子的粪便脂肪酸表明 生物氢化作用确实发生在它们的肠道中，产生反式脂肪 似乎被结合到红细胞膜中的酸。 在研究开始后的6周内， 喂食实验饲料的猴子含有10.8%的反式 总脂肪酸的十八酸异构体。对应 随着反式脂肪酸的增加， 膜亚油酸与花生四烯酸之比。这表明， 反式脂肪酸干扰花生四烯酸的合成。那里 也是饱和脂肪酸和顺式脂肪酸的置换 十八酸异构体。计算了双键指数，并计算了双键指数 表明观察到的脂肪酸中的扰动 喂食红细胞膜的猴红细胞膜含量 实验日粮导致膜流动性降低。

The study will examine the metabolism of exogenous fatty acids by Macaca fascicularis. Trans fatty acids which cannot be synthesized by eukaryotes will be used as the exogenous fatty acid marker. These fatty acids are geometrical isomers of cis fatty acids which can be synthesized by eukaryotes. The trans fatty acids are catabolized and removed from the body shortly after the fatty acids are removed from the diet. Twelve male M. fascicularis monkeys were used in the study. Six were fed the control diet, and the others received the experimental diet. The RBC membrane of monkeys fed the control diet contained .5% trans octadecanoate isomers of the fatty acids. Examination of the fecal fatty acids from these monkeys showed that biohydrogenation does occur in their gut producing trans fatty acids which appear to be incorporated into the RBC membrane. Within 6 weeks after initiating the study the RBC membranes of monkeys fed the experimental diet contained 10.8% trans octadecanoate isomers of the total fatty acids. Corresponding with the increase in trans fatty acids there was an increase in the membrane linoleate to arachidonate ratio. This indicated that trans fatty acids interfere with arachidonate synthesis. There was also a displacement of saturated fatty acids and cis octadecanoate isomers. The double bond index was calculated and indicated that the observed perturbations in the fatty acid content of the RBC membranes from monkeys fed the experimental diet resulted in decreased membrane fluidity.