FLUORESCENCE-GUIDED LASER ANGIOPLASTY IN PERIPHERAL VASCULAR DISEASE

一种以荧光光谱为导向的新型双激光系统 对脉冲染料激光组织消融的方式进行了研究。 作为合作的一部分的股四叉关节闭塞患者 多中心评估。这种设备最初的构思和开发是 美国国立卫生研究院-工业联合研究的一项产品目前正在美国10个中心使用 美国和法国。该系统在激光血管成形术中是独一无二的 提供了治疗激光的实时引导装置 利用荧光光谱识别建议的目标位置 这应该会大大提高再通的效果，并减少 穿壁穿孔的频率。这项研究中接受治疗的患者 有不同长度的股骨干动脉闭塞，不能 使用标准的球囊血管成形术成功治疗。在这 患者队列，使用单光纤激光设备进行初次再通 81%的患者成功，随后是成功的气囊 74%的患者接受了血管成形术。他们没有严重的并发症，而且 荧光光谱学有助于在某些情况下识别血栓。 同花顺的主干闭塞终止于一个大的分支侧支 容器，以及偏心纤维位置接近的情况下 下层介质威胁血管壁穿孔。我们相信这一点 具有实时引导能力的先进激光血管成形术系统将 是治疗冠状动脉和外周血管的重要工具 疾病。

A new dual laser system utilizing fluorescence spectroscopy as a guidance modality for pulsed dye laser tissue ablation has been studied in 70 patients with femoropopliteal occlusions as part of a cooperative multi-center evaluation. This device, originally conceived and developed as a product of joint NIH-industry research is now being used in 10 centers in the United States and France. The system is unique among laser angioplasty devices in that real-time guidance of the treatment laser is provided utilizing florescence spectroscopic identification of proposed target sites which should greatly improve recanalization efficacy and reduce the frequency of transmural perforations. The patients treated in this study had femoropopliteal occlusions of varying lengths which could not be treated successfully using standard balloon angioplasty techniques. In this patient cohort, primary recanalization using the single fiber laser device was successful in 81% of patients followed by successful balloon angioplasty in 74% of patients. Their were no major complications and florescence spectroscopy was helpful in identifying thrombus, in situations of flush main channel occlusions terminating in a large branch collateral vessel, and under circumstances when eccentric fiber position approached underlying media threatening vessel wall perforation. We believe that this advanced laser angioplasty system with real-time guidance capabilities will be an important tool in the treatment of coronary and peripheral vascular disease.