DISADVANTAGES OF ARGON LASERS FOR ANGIOPLASTY

氩激光器用于血管成形术的缺点

• 批准号: 4694689
• 负责人: M B LEON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694689
• 关键词: argon; biomedical equipment safety; clinical biomedical equipment; human tissue; thermography

This work was performed to help define the characteristics associated with argon ion lasers which are the most frequently used laser source in animal and human research for intravascular tissue ablation. Argon lasers were studied in air, blood, saline, and saline blood mixtures in an attempt to define the mechanism of tissue ablation and sorrounding thermal difusion characteristics. A uniform methodology was employed including careful ocular michrometry and thermographic analyses utilizing adventitial mechanical thermocouples and fast infra-red surface thermography. We found that argon lasers cause nonuniform large-step explosive vaporization of tissue followed by tissue combustion which is associated with marked radial thermal diffusion. Argon lasers appear to be a disadvantageous source for angioplasty given the lack of precision, marked variability in ablative effects, and widespread thermal diffusion to sorrounding normal tissues.

进行这项工作是为了帮助定义与 氩离子激光器是动物实验中最常用的激光源 和人体血管内组织消融的研究。 氩激光器 在空气、血液、盐水和盐水血液混合物中进行研究， 明确组织消融和周围热扩散的机制 特色 采用了统一的方法， 利用外膜的眼部显微测量和热像分析 机械热电偶和快速红外表面热成像。 我们发现 氩激光导致不均匀的大台阶爆炸汽化， 组织燃烧，与明显的径向 热扩散 氩激光器看起来是一种不利的源， 血管成形术缺乏精确性， 影响，以及广泛的热扩散到周围的正常组织。