STENT IMPLANTATION IN VALVED CONDUITS

带阀导管中的支架植入

• 批准号: 3920182
• 负责人: M B LEON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920182
• 关键词: Cercopithecidae; implant; prosthetic heart valve; pulmonary artery; pulmonary valve stenosis

Although valved conduits have been used successfully in severe forms of right ventricular-pulmonary artery discontinuity, progressive valved conduit stenosis is an important clinical problem. Therefore, we employed a balloon expandable stent in a baboon model consisting of pulmonary artery ligation and implantation of an RV-PA 14 mm bioprosthetic dacron valved conduit. We were able to deploy the balloon expandable stent within the stenotic portion of the valved conduit and in most animals achieved significant reduction in RV systolic pressure and valved conduit gradient. Therefore, we believe the balloon expandable stent may be a useful technique to prolong the patency of right heart valved conduits in patients.

虽然带瓣管道已成功地用于严重的 右心室-肺动脉不连续的形式， 进行性瓣膜管道狭窄是一个重要的临床 问题. 因此，我们采用了球囊扩张支架， 狒狒模型，包括肺动脉结扎和 植入RV-PA 14 mm生物假体涤纶带瓣管道。 我们能够将球囊扩张支架在 在大多数动物中， RV收缩压和带瓣管道显着降低 梯度离心 因此，我们认为球囊扩张支架可以 是延长右心瓣膜开放时间的有效技术 患者体内的导管