PREFERENTIAL LASER ABLATION OF PIGMENTED ATHEROMA

为了帮助开发一种理解的新的激光光源 临床激光血管成形术，定量评估 以查看组织消融效率是否依赖于 人体斑块成分。先前的反射率和透射率 可变成分尸检主动脉的光谱分析显示 黄色动脉粥样硬化在460-500 nm处有较高的吸收。因此， 两个激光光源-脉冲染料激光器(480 Nm)和连续染料激光器 用Ar激光(488 Nm)烧蚀变成分 尸检动脉粥样硬化标本。对于这两个激光光源， 黄色动脉粥样硬化的消融效率提高了5-10倍 相对于白色动脉粥样硬化和正常大动脉。因此，我们有 黄色素沉着斑块选择性消融 使用特定激光光源的动脉粥样硬化材料 波长(脉冲或低功率连续) 与较高的组织吸收特性相对应。这些数据 在允许更安全和更有效的动脉粥样硬化方面可能很重要 实验性激光治疗中特殊临床情况下的消融 血管成形术调查。

In an effort to help develop an understand new laser sources for clinical laser angioplasty, quantitative evaluations were performed to see if tissue ablation efficiency was dependent upon human plaque composition. Previous reflectance and transmission spectroscopy on variable composition necropsy aorta showed higher absorption at 460-500nm by yellow atheroma. Therefore, two laser sources - a pulsed dye laser (480nm) and a continuous Argon laser (488nm) were used to ablate variable composition necropsy atherosclerotic specimens. For both laser sources, the ablation efficiency increased 5-10 fold for yellow atheroma relative to both white atheroma and normal aorta. Thus, we have demonstrated selective plaque ablation of yellow pigmented atherosclerotic material using laser sources of a specific wavelength (either pulsed or low-power continuous) which correspond to higher tissue absorption characteristics. These data may be important in permitting safe and more efficient atheroma ablation in specific clinical situations during experimental laser angioplasty investigations.