FLUORESCENCE-GUIDED LASER ANGIOPLASTY IN PATIENTS

患者的荧光引导激光血管成形术

• 批准号: 3920178
• 负责人: M B LEON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920178
• 关键词: artery stenosis; atherosclerosis; clinical biomedical equipment; fluorescence spectrometry; human subject

A prototype dual laser system employing fluorescence spectroscopy for plaque recognition combined with a pulsed dye laser for tissue ablation was utilized to perform fluorescence guided, laser assisted balloon angioplasty in patients with femoro-popliteal occlusions. In 10 patients, we demonstrated successful real-time fluorescence-guided pulsed dye laser ablation of obstructions but noted difficulty with both laser and subsequent balloon angioplasty of heavily calcified lesions. This early clinical experience will permit us to modify delivery systems such that larger laser angioplasty channels may be created with increased catheter tip control. In addition, we have begun preliminary studies in patients with chronic total coronary occlusions using a similar fluorescence guided laser system. This will be the first attempt at percutaneous laser recanalization of chronic total coronary occlusions in humans and results are forthcoming.

采用荧光光谱的双激光系统原型