PARTICULATE DEBRIS FROM ROTATIONAL ATHERECTOMY

旋转斑块切除术产生的颗粒碎片

• 批准号: 3920180
• 负责人: M B LEON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920180
• 关键词: atherosclerosis; heart circulation; human tissue; intraluminal angioplasty; laboratory rat; microcirculation; particle counter; radiotracer

Rotational atherectomy catheters can ablate atheroma and restore patency in atherosclerotic arteries but little is known about the resultant particulate debris or its effect on myocardial blood flow. Therefore, we examined particulate debris number and size distribution after ablation of human necropsy aorta utilizing a sophisticated laser fluorescence and light scattering particle counter. Almost 90% of the particles were less than 12 microns in size and 80% were less than 5 microns in size. To determine the acute in vivo effects of particle debris on myocardial blood flow, carefully graded injections of particulate were infused into the left circumflex coronary artery of dogs and blood flow was measured using radio-labeled microspheres. Preliminary results indicate that only very large doses of calcified particulate caused deleterious hemodynamic effects. These studies will be continued to formalize our understanding of the safe particle burden which could be tolerated by the coronary microcirculation without significant effects on myocardial blood flow and/or left ventricular hemodynamics.

旋切术导管可以消融动脉粥样硬化， 动脉粥样硬化动脉的通畅性，但人们对其知之甚少 产生的颗粒碎片或其对心肌血液的影响 流 因此，我们检查了颗粒碎片的数量和大小 使用一种方法消融人体尸检主动脉后的分布 复杂的激光荧光和光散射粒子 柜台 几乎90%的颗粒小于12微米， 尺寸和80%小于5微米。 确定 颗粒碎片对心肌血流的急性体内影响， 仔细分级的颗粒注射被注入到 取犬冠状动脉左回旋支，测定血流量 使用放射性标记的微球。 初步结果表明 只有大剂量的钙化颗粒 有害的血液动力学效应。 这些研究将继续进行。 使我们对安全粒子负荷的理解正式化， 冠状动脉微循环可以耐受， 对心肌血流量和/或左心室 心室血流动力学