AMIODARONE THERAPY IN PATIENTS WITH HCM AND REFRACTORY CARDIAC SYMPTOMS
AMIODARONE THERAPY IN PATIENTS WITH HCM AND REFRACTORY CARDIAC SYMPTOMS
批准号:
3966723
负责人:
M B LEON
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
一项正在进行的临床试验被制定来评估治疗效果
英文摘要
An ongoing clinical trial was formulated to assess therapeutic efficacy of
high dose oral amiodarone in patients with hypertrophic cardiomyopathy and
refractory cardiac symptoms compared with standard pharmacologic agents and
to characterize hemodynamic and left ventricular functional responses
associated with amiodarone to help define mechanisms of action. Thusfar,
40 patients with refractory cardiac symptoms on standard medical therapies
have been studied as inpatients on the Cardiology Service and have been
seen as outpatients at 2 months, 6 months, and 1 year after instituting
oral amiodarone treatment. After stopping medications for several days in
the hospital, high dose oral amiodarone resulted in beneficial clinical
responses (defined as at least a 50% improvement in exercise performance
compared with no medication values and a decrease in cardiac symptoms by at
least one functional class) in 68% of the patient group. During chronic
lower dose outpatient amiodarone treatment, improvement was generally
maintained (63% clinical responders); some patients manifested further
symptom benefit, and in others symptoms were worse compared with higher
dose acute treatment. As might be expected in this group of severely
symptomatic patients unresponsive to standard pharmacologic therapy, many
patients failed to experience maintained clinical benefit. Nonetheless,
45% of the total patient cohort are still receiving amiodarone for an
average follow-up of 14 months and have continued to describe persistent
improvement in symptoms. One half of all patients with left ventricular
outflow tract obstruction who were deemed operative candidates prior to
initiating amiodarone have experienced sufficient symptomatic improvement
so that surgery could be deferred. From this ongoing clinical trial we
conclude that high dose oral amiodarone improves exercise capacity and
reduces cardiac symptoms in the majority of patients with hypertrophic
cardiomyopathy who have been refractory to standard medical therapy and
long-term clinical follow-up indicates a modest diminution in clinical
efficacy although almost one half of all patients have continued treatment
after the first year with continued symptomatic improvement.
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FLOW TURBULENCE INDUCED BY CORONARY STENTS
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批准号:3899257
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
CHRONIC EFFECTS OF AMIODARONE IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
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批准号:4694676
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
PARTICULATE DEBRIS SIZE FROM EXCIMER AND ARGON LASER ABLATION
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批准号:3942967
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
FLUORESCENCE-GUIDED LASER ANGIOPLASTY IN PATIENTS
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批准号:3920178
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
STENT IMPLANTATION IN VALVED CONDUITS
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批准号:3920182
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
PARTICULATE DEBRIS FROM ROTATIONAL ATHERECTOMY
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批准号:3920180
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
A NEW ERBIUM LASER AND INFRARED FIBER SYSTEM FOR LASER ANGIOPLASTY
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批准号:3942938
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
LASER-INDUCED FLUORESCENCE PLAQUE DETECTION IN PATIENTS
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批准号:3942964
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
SEEDING OF INTRAVASCULAR STENTS WITH GENETICALLY ENGINEERED ENDOTHELIAL CELLS
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批准号:3899254
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
CORONARY STENT IMPLANTATION IN PATIENTS AFTER MULTIPLE PTCA RESTENOSIS
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批准号:3899256
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
ABNORMAL FIBRYNOLITIC ACTIVITY IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
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批准号:4694695
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
AMIODARONE IMPROVES RAPID DIASTOLIC FILLING IN PATIENTS WITH HCM
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批准号:4694677
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
DISADVANTAGES OF ARGON LASERS FOR ANGIOPLASTY
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批准号:4694689
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
SLOTTED AND TUBULAR BALLOON EXPANDABLE STENTS ACROSS VEIN GRAFT ANASTOMOTIC SITES
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批准号:3899251
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
AMIODARONE THERAPY IN PATIENTS WITH HCM AND REFRACTORY CARDIAC SYMPTOMS
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批准号:3942937
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
FLUORESCENCE-GUIDED LASER ANGIOPLASTY IN PERIPHERAL VASCULAR DISEASE
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批准号:3899253
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
FLUORESCENCE-GUIDED LASER ANGIOPLASTY USING MULTIFIBER LASER CATHETERS
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批准号:3899255
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
PREFERENTIAL LASER ABLATION OF PIGMENTED ATHEROMA
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批准号:3942968
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
REDUCED SURFACE THROMBEGENICITY AFTER THERMAL ABLATION OF PLAQUE
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批准号:3942966
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位:
RESPONSES OF CANINE ARTERIAL WALL TO EXCIMER LASER IRRADIATION
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批准号:3942965
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M B LEON
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依托单位: