PARTICULATE DEBRIS SIZE FROM EXCIMER AND ARGON LASER ABLATION

准分子和氩激光烧蚀的颗粒碎片尺寸

• 批准号: 3942967
• 负责人: M B LEON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942967
• 关键词: atherosclerosis; biomedical equipment safety; clinical biomedical equipment; embolism; human tissue; infrared radiation; particle; ultraviolet radiation; visible light

Feasibility of clinical laser angioplasty will depend upon safe and efficacious removal of obstructing intravascular atheroma. However, different laser sources (visible, infrared, or ultraviolet) and variable lasing parameters (pulsed vs continuous) result in different tissue effects due to different mechanisms of tissue ablation. Since particulate debris after atheroma removal may result in hemodynamically important intraarterial embolic events, it becomes necessary to characterize the photo-products of laser ablation before these techniques can be considered for clinical application. Thus, we determined the size distribution of particular debris after laser ablation of full thickness holes in normal necropsy aorta under saline using a pulsed ultraviolet excimer laser and a continuous argon laser. For both laser sources, more than 80% of particulate debris was less than 3 microns in size, suggesting that the majority of photo-products are too small to cause microvascular obstruction. Interestingly, the excimer laser, despite less thermal tissue injury, caused a 5- 10 fold greater number of particles which are greater than 5 microns in size. Since pulsed excimer laser tissue ablation creates shock waves, this mechanism of tissue ablation may result in a larger particle size distribution which may be disadvantageous.

临床激光血管成形术的可行性将取决于安全性和 有效清除阻塞血管内动脉粥样硬化。 然而，不同的激光源（可见光、红外线或紫外线） 和可变激光参数（脉冲与连续）导致 由于组织的不同机制而产生不同的组织效应 消融术 由于去除动脉粥样硬化后的颗粒碎片可能 导致血流动力学上重要的动脉内栓塞事件， 有必要对激光的光产物进行表征， 在这些技术可以考虑用于临床之前进行消融 应用程序. 因此，我们确定了 激光烧蚀全厚度孔后， 使用脉冲紫外线在盐水下正常尸检主动脉 准分子激光器和连续氩激光器。 对于两种激光 来源，超过80%的颗粒碎片小于3 微米大小，这表明大多数照片产品 太小而不会造成微血管阻塞 有趣的是， 准分子激光，尽管较少的热组织损伤，造成5- 大于5的颗粒数量为10倍 微米大小。 由于脉冲准分子激光组织消融 产生冲击波，这种组织消融机制可能导致 在较大的粒度分布中， 不利。