A dendritic cell subset targeting approach for defining immune function and tailoring immunotherapy

用于定义免疫功能和定制免疫治疗的树突状细胞子集靶向方法

• 批准号: nhmrc : 516727
• 负责人: A/Pr Irina Caminschi
• 金额: $ 46.19万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dendritic-cell-subset-tailoring-immunotherapy/96443
• 关键词: dendritic; cell; subset; targeting; approach

Dendritic cells are important sentinel cells of the immune system that orchestrate our immune responses against invading pathogens. There are different types of dendritic cells and they perform different jobs. We have a series of antibodies that can recognise markers on the surface of different dendritic cells populations. We can use these antibodies as homing devices to deliver foreign material to individual dendritic cell subpopulations and thereby manipulate the type of immune response generated. Effectively, we aim to tailor immune responses to fight a particular bacteria, virus, parasite, or even cancer cells. The current proposal will extend the number of antibodies we test for their ability to generate tailored immunity. We will examine a number of new molecules for their ability to shuttle foreign material to dendritic cells and their ability to stimulate immune responses. Next, we will test these homing devices as vaccines and their ability to prevent or treat cancer. Our aim is to develop a robust, highly efficient, generic, vaccination approach for cancer immunotherapy.

树突状细胞是免疫系统的重要前哨细胞，负责协调我们针对入侵病原体的免疫反应。树突状细胞有不同类型，它们执行不同的工作。我们拥有一系列可以识别不同树突状细胞群表面标记的抗体。我们可以使用这些抗体作为归巢装置，将外来物质递送至单个树突细胞亚群，从而操纵产生的免疫反应的类型。实际上，我们的目标是定制免疫反应来对抗特定的细菌、病毒、寄生虫，甚至癌细胞。目前的提案将扩大我们测试产生定制免疫能力的抗体数量。我们将检查许多新分子将外来物质运送到树突状细胞的能力以及刺激免疫反应的能力。接下来，我们将测试这些导航设备作为疫苗及其预防或治疗癌症的能力。我们的目标是开发一种稳健、高效、通用的癌症免疫治疗疫苗接种方法。