The identification and characterisation of a new DNA receptor

新DNA受体的鉴定和表征

• 批准号: nhmrc : 1060522
• 负责人: A/Pr Irina Caminschi
• 金额: $ 43.78万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-characterisation-new-dna-receptor/454835
• 关键词: identification; characterisation; new; DNA; receptor

The immune system has evolved to fight disease-causing microbes. First, it has to recognize that an infectious agent has invaded. To do this we have developed many probes (receptors) that sense microbial products. Detecting microbial DNA is a critical alarm bell. However, distinguishing pathogen DNA from our own DNA is difficult because both look alike. We have identified a new receptor that helps us identify bacterial DNA and alerts the immune system to the imminent danger.

免疫系统已经进化到对抗致病微生物。首先，它必须认识到一种传染性病原体已经入侵。为了做到这一点，我们已经开发了许多探针（受体），感觉微生物产品。检测微生物DNA是一个关键的警钟。然而，将病原体DNA与我们自己的DNA区分开来是困难的，因为两者看起来很相似。我们已经发现了一种新的受体，可以帮助我们识别细菌DNA，并提醒免疫系统即将发生的危险。