The regulatory role of Clec12A in antigen presentation and inflammatory disease

Clec12A 在抗原呈递和炎症性疾病中的调节作用

• 批准号: nhmrc : 1142358
• 负责人: A/Pr Irina Caminschi
• 金额: $ 93.38万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulatory-role-clec12a-inflammatory-disease/1319683
• 关键词: regulatory; role; Clec12A; antigen; presentation

The immune system maintains a balance between initiating immune responses to infections and suppressing immune responses in health. We have identified, on the surface of specialised immune cells, a protein that is critical for regulating immune responses and dampening down inflammation. This proposal aims to determine how this protein functions in health and under inflammatory conditions, and to develop approaches based on its molecular interactions to reduce inflammatory disease.

免疫系统在启动对感染的免疫反应和抑制健康的免疫反应之间保持平衡。我们已经在专门的免疫细胞表面发现了一种对调节免疫反应和抑制炎症至关重要的蛋白质。该提案旨在确定这种蛋白质在健康和炎症条件下如何发挥作用，并开发基于其分子相互作用的方法来减少炎症性疾病。