Targeting antigen to Clec9A on dendritic cell for humoral immunity

将抗原靶向树突状细胞上的 Clec9A 以实现体液免疫

• 批准号: nhmrc : GNT1124706
• 负责人: A/Pr Irina Caminschi
• 金额: $ 74.46万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-antigen-clec9a-humoral-immunity/1347428
• 关键词: Targeting; antigen; Clec9A; dendritic; cell

Dendritic cells capture infectious organisms and display them to other immune cells to initiate immunity. The process of capturing organisms requires dendritic cells to express a variety of cell-surface receptors that detect components carried by infectious agents. Here we will examine the efficacy of attaching vaccine components to a targeting agent that binds one of these receptors with the aim of enabling dendritic cells to efficiently kick-start immunity against vaccine components.

树突状细胞捕获感染性生物体并将其展示给其他免疫细胞以启动免疫。捕获生物体的过程需要树突状细胞表达多种细胞表面受体，以检测感染因子携带的成分。在这里，我们将研究将疫苗成分连接到结合这些受体之一的靶向剂上的功效，目的是使树突状细胞能够有效地启动针对疫苗成分的免疫。