The role of the dendritic cell surface molecule Clec9A in dendritic cell subset function and dead cell recognition

树突状细胞表面分子Clec9A在树突状细胞亚群功能和死细胞识别中的作用

• 批准号: nhmrc : 575546
• 负责人: A/Pr Irina Caminschi
• 金额: $ 35.13万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dendritic-cell-cell-recognition/98304
• 关键词: role; dendritic; cell; surface; molecule

Dendritic cells (DC) are sentinels of the immune system. DC monitor the environment and regulate tolerance to self versus immunity to dangerous material. Different types of DC perform different jobs. We have identified a new surface molecule, Clec9A, on some mouse and human DC. We will investigate the function of Clec9A in the immune response. We will also use Clec9A to help unite mouse and human DC biology, since until now there have been few useful marker molecules common to both species.

树突状细胞（DC）是免疫系统的哨兵。DC监控环境并调节对自身的耐受性和对危险物质的免疫力。不同类型的DC执行不同的工作。我们已经在一些小鼠和人DC上鉴定了一种新的表面分子Clec9A。我们将研究Clec9A在免疫应答中的功能。我们还将使用Clec9A来帮助统一小鼠和人类DC生物学，因为到目前为止，这两个物种几乎没有共同的有用标记分子。