Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells

树突状细胞上的 DAMP 受体 Clec9A 有效加工抗原的分子基础

• 批准号: nhmrc : GNT1082665
• 负责人: A/Pr Irina Caminschi
• 金额: $ 124.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-efficient-dendritic-cells/1345473
• 关键词: Molecular; basis; efficient; processing; antigens

Dendritic cells (DC) of the immune system utilise specific receptors to sense danger signals from their environment. We identified a DC danger receptor, Clec9A, which recognizes and induces immunity to “dangerous” dead cells eg. infected cells or killed tumour cells. We will investigate how DC use Clec9A to process “dangerous” dead cells, and the factors that control the potency of this immune response. This will enable us to develop novel immunotherapies for infectious diseases and cancer.

免疫系统的树突状细胞(DC)利用特定的受体来感知来自环境的危险信号。我们鉴定了一种DC危险受体，Clec9A，它识别并诱导对“危险”死亡细胞的免疫，例如。感染细胞或杀死肿瘤细胞。我们将研究DC如何使用Clec9A来处理“危险的”死亡细胞，以及控制这种免疫反应效力的因素。这将使我们能够开发针对传染病和癌症的新型免疫疗法。