Enhancing vaccine efficacy by harnessing dendritic cell receptors and their unique properties

利用树突状细胞受体及其独特特性增强疫苗功效

• 批准号: nhmrc : 1060519
• 负责人: A/Pr Irina Caminschi
• 金额: $ 45.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhancing-vaccine-efficacy-unique-properties/454834
• 关键词: Enhancing; vaccine; efficacy; harnessing; dendritic

Potent vaccination might be achieved by using monoclonal antibodies as magic bullets to target vaccines to special cells in the body. We show that targeting these special cells by using monoclonal antibodies that recognise Clec9A is effective, perhaps because it brings several different immune cells together so that they orchestrate very efficient immune responses. This application investigates how targeting Clec9A allows strong vaccination so that we can apply this to new generation vaccines.

通过使用单抗作为灵丹妙药，将疫苗靶向体内的特殊细胞，可以实现有效的疫苗接种。我们表明，通过使用识别Clec9A的单抗来靶向这些特殊细胞是有效的，可能是因为它将几种不同的免疫细胞聚集在一起，使它们协调非常有效的免疫反应。这个应用程序调查了针对Clec9A如何实现强大的疫苗接种，以便我们可以将其应用于新一代疫苗。