Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells
Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells
批准号:
nhmrc : 1082665
负责人:
A/Pr Irina Caminschi
金额:
$86.84万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2019-12-31
中文摘要
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英文摘要
Dendritic cells (DC) of the immune system utilise specific receptors to sense danger signals from their environment. We identified a DC danger receptor, Clec9A, which recognizes and induces immunity to “dangerous” dead cells eg. infected cells or killed tumour cells. We will investigate how DC use Clec9A to process “dangerous” dead cells, and the factors that control the potency of this immune response. This will enable us to develop novel immunotherapies for infectious diseases and cancer.
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会议论文
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批准号:nhmrc : 1142358
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项目类别:Project Grants
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资助金额:$93.38万
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财政年份:2018
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负责人:A/Pr Irina Caminschi
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依托单位:
The regulatory role of Clec12A in antigen presentation and inflammatory disease
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负责人:A/Pr Irina Caminschi
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依托单位:
Targeting antigen to Clec9A on dendritic cell for humoral immunity
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项目类别:Project Grants
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财政年份:2017
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负责人:A/Pr Irina Caminschi
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依托单位:
Targeting antigen to Clec9A on dendritic cell for humoral immunity
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项目类别:Project Grants
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资助金额:$74.46万
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财政年份:2017
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负责人:A/Pr Irina Caminschi
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依托单位:
Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells
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项目类别:Project Grants
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依托单位:
A new DNA receptor
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依托单位:
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依托单位:
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批准号:nhmrc : 575546
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项目类别:NHMRC Project Grants
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资助金额:$35.13万
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财政年份:2009
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依托单位:
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海外基金
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