CELL-CELL INTERACTION BETWEEN ORAL ACTINOMYCETES AND OTHER ORAL BACTERIA

口腔放线菌和其他口腔细菌之间的细胞间相互作用

• 批准号: 3917100
• 负责人: P E KOLENBRANDER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3917100
• 关键词: Actinomycetales; Bacteroides; Bacteroides gingivalis; Fusobacterium; Streptococcus mitis; Streptococcus salivarius; Streptococcus sanguis; adhesin; bacterial virus; cell aggregation; cell cell interaction; dental plaque; genetic strain; gingiva; gram negative bacteria; gram positive bacteria; host organism interaction; lectin; microorganism immunology; monoclonal antibody; mutant; oral bacteria; periodontium disorder

As additional information regarding cell-to-cell recognitions among oral bacteria is discovered, it is becoming increasingly clear that a dynamic but organized microbial community exists in the oral cavity. The part of this complex community studied in this laboratory pertains especially to microbial ecology. Both gram- positive an gram-negative bacteria are tested as coaggregation partners. The concept of highly specific partnerships advanced by this laboratory gained additional support with the evidence that strains of Bacteroides gingivalis, a presumed periodontal pathogen, coaggregates with Fusobacterium nucleatum and Eubacterium nodatum, strains, that are also associated with periodontal disease, but not with any other oral strains. Some coaggregations are inhibited by lactose, which adds to the growing number of sugar-inhibitable pairings among the oral bacteria. An intensive survey of strains of Veillonella from the tongue, buccal mucosa, and saliva revealed that veillonellae from the tongue coaggregate with Streptococcus salivarius, also a tongue inhabitant, but not with subgingival bacteria. Whereas, veillonellae from subgingival plaque coaggregate with other subgingival bacteria but not with S. salivarius. These results provide the first direct evidence that coaggregation is tightly coupled to the ability of a strain to colonize a specific econiche. The results of each of these investigative approaches are focused on understanding the relationship of cell surface recognitions among oral bacteria and their role in microbial ecology.

作为关于小区到小区之间的切换的附加信息， 口腔细菌被发现后，越来越清楚的是， 口腔中存在一个动态但有组织的微生物群落， 腔 本书中研究的这一复杂群落的一部分 实验室特别与微生物生态学有关。 两克- 阳性和革兰氏阴性细菌被测试为共聚集 伙伴 高度具体的伙伴关系概念是由 这个实验室获得了额外的支持， 牙龈拟杆菌菌株，一种假定的牙周病原体， 与具核梭杆菌和结节真杆菌共聚集， 菌株，也与牙周病有关，但与 与其他口腔菌株的关系 一些聚集被抑制， 乳糖，这增加了越来越多的糖代谢 口腔细菌的配对。 一项对舌头上韦荣氏球菌菌株的深入调查， 口腔粘膜和唾液显示， 舌与唾液链球菌共聚集，也是舌 居民，但不是与龈下细菌。 鉴于： 龈下菌斑与其他菌斑共聚集 龈下细菌，但不与S.唾液 这些结果 提供了第一个直接的证据，表明共聚集是紧密的， 再加上菌株能够在特定的生态块上定居。 每一种调查方法的结果都集中在 了解细胞表面结构之间的关系 以及它们在微生物生态学中的作用。