ANIMAL MODELS OF ATHEROSCLEROSIS

补充正在进行的研究，包括血管镜检和激光组织检查 相互作用，开发一种可繁殖的动物已经变得必要 动脉粥样硬化模型。测试多功能导尿管样机 为了模拟单临床条件，我们使用了各种 动物实验室里的模型。到目前为止，已经有14头小型猪 作为致动脉粥样硬化饮食(胆固醇水平500-1,000)的组合 Mg/dl)和血管内球囊内皮剥脱术 在透视下使用无菌外科技术。从一首歌 行股动脉切断术，颈动脉球囊剥脱术。 双侧髂股动脉。紧随其后获得的血管造影术 气囊诱导的气压伤显示受影响的变形性血管痉挛 船只。我们在一到三个月后检查了几只动物 在成熟过程中因各种原因死亡的初始程序 研究的阶段。重度和晚期局灶性动脉粥样硬化病变 在气球剥落的部位观察到钙化， 组织化血栓和“人”状动脉粥样硬化形态。在……里面 此外，我们还在主动脉和髂股进行了球囊剥脱术。 20只新西兰大白兔也接受致动脉粥样硬化的饮食。 在手术几周后死亡的几只兔子的尸检样本， 显示主动脉内脂肪条纹损害较轻，病灶较多 髂动脉血流动力学明显异常。我们相信 这两种动脉粥样硬化模型非常适合帮助研究 体内激光血管成形术的可行性。

To complement ongoing studies including angioscopy and Laser-tissue interactions, it has become necessary to develop a reproducible animal model of atherosclerosis. To test prototype multifunctional catheters in an attempt to simulate uniclinical conditions, we have employed a variety of models in the animal laboratory. Thusfar, 14 miniature swine have been placed as combination of atherogenic diet (cholesterol levels 500-1,000 mg/dl mg/dl) and intravascular balloon endothelial denudation performed under fluoroscopy utilizing sterile surgical techniques. From a single femoral arterial cutdown, balloon denudation was performed in carotid and iliofemoral arteries bilaterally. Angiograms obtained immediately after balloon-induced barotrauma revealed varked vasospasm of the affected vessels. We have examined several animals at one-three months after the initial procedure who have died for various reasons during the maturation phase of the study. Intense and advanced focal atherosclerotic lesions were observed at the sites of balloon denudation consisting of calcified, organized thrombus and "human" appearing antherosclerotic morphology. In addition, we have performed balloon denudation in the aorta and iliofemoral system of 20 New Zealand white rabbits also receiving an atherogenic diet. Necropsy specimens in several rabbits who died weeks after the procedure, revealed less intense fatty streak lesions in the aorta with more focal hemodynamically significant abnormalities in the iliac vessels. We believe that these two models of atherosclerosis are well suited to help study the feasibility of in vivo laser angioplasty.