GENETIC CONTROL OF RESISTANCE TO FRIEND VIRUS IN WILD MOUSE POPULATIONS

野生小鼠群体对朋友病毒抵抗力的基因控制

• 批准号: 3960531
• 负责人: C A KOZAK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3960531
• 关键词: Friend virus; R factors; gene expression; genetic mapping; genetic regulation; genetic strain; microorganism immunology; molecular biology; molecular cloning; neoplasm /cancer genetics; neoplasm /cancer immunology; nucleic acid sequence; provirus; surface antigens; viral leukemogenesis; virus related neoplasm /cancer; virus replication

Studies on viral leukemogenesis in wild mice have shown that these mice differ substantially from the inbred strains. First, feral mice contain many fewer chromosomally integrated MuLV related sequences than inbred mice. Second, the ecotropic virus isolates from M. hortulanus, M. m. castaneus, and M. cervicolor differ from the ecotropic MuLVs of inbred mice in their biochemical and biological properties. Third, cells of most wild mice differ from inbred mice in their susceptibility to exogenous infection by ecotropic and xenotropic MuLVs. Most feral mice carry a novel non-restrictive allele at the Fv-1 locus and some Maryland wild mice show an unusual resistance to NB-tropic virus. Cells of most feral mice, but not laboratory mice, are susceptible to xenotropic MuLVs. This trait is controlled by a single chromosome 1 locus, designated Sxv which may represent a wild mouse polymorphism of the MCF-MuLV receptor locus.

对野生小鼠病毒性白血病的研究表明，这些小鼠 与近交系有很大的不同。首先，野鼠含有 与近交系相比，染色体整合的MuLV相关序列要少得多 老鼠。其次，从红豆杉、红曲霉、红豆杉等分离 Castaneus和M.cervicolor与近交系小鼠的生态型MuLV不同 在它们的生化和生物学特性上。第三，大多数野生动物的细胞 小鼠与近交系小鼠对外源感染的易感性不同 生态型和异构型MULV。大多数野鼠都带着一本小说 FV-1基因座的非限制性等位基因和一些马里兰野鼠显示 对嗜NB病毒具有不同寻常的抵抗力。大多数野鼠的细胞，但 而不是实验室小鼠，对异质性MULV易感。这一特点是 由单个染色体1基因座控制，命名为Sxv，它可能 代表MCF-MuLV受体基因座的野鼠多态。