CELLULAR GENES INVOLVED IN TRANSFORMATION AND MULV TRANSMISSION IN INBRED MICE

近交系小鼠中参与转化和多病毒传播的细胞基因

• 批准号: 3818178
• 负责人: C A KOZAK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3818178
• 关键词: Drosophilidae; Retroviridae disease; cell transformation; chromosomes; cytochromes; gene expression; genetic manipulation; genetic mapping; genetic regulation; hybrid cells; laboratory mouse; lymphoma; molecular cloning; murine leukemia virus; neoplasm /cancer genetics; nucleic acid probes; nucleic acid sequence; proteins; protooncogene; sperm; stress proteins; tissue /cell culture; tumor antigens; virus antigen; virus genetics; virus infection mechanism

Numerous chromosomal gene shave been identified which are involved in retrovirus-induced disease and the transmission of retroviral genes in the inbred mouse. Genetic mapping of these genes to specific mouse chromosomes has been accomplished by the analysis of Chinese hamster x mouse somatic cell hybrids each of which contains different mouse chromosomes. In some cases, genes have also been mapped to subchromosomal regions or to specific map locations along these chromosomes by use of classical Mendelian crosses. These studies have led to chromosomal mapping of genes encoding the tumor rejection antigen gp96, the Fms and Met proto- oncogenes and a sequence which may represent the ecotropic MuLV cell surface receptor. The somatic cell hybrids have also been used to map other chromosomal gene for which cloned probes are available. Most recently, we have mapped genes for spermatid associated proteins, genes related to Drosophila heat shock proteins, P450 cytochromes, and several T lymphocyte antigens.

许多染色体基因已被确定， 逆转录病毒引起的疾病和逆转录病毒的传播 近交系小鼠的基因。 这些基因的遗传图谱， 特异性小鼠染色体的分析已经完成 中国仓鼠x小鼠体细胞杂交体， 含有不同的老鼠染色体 在某些情况下，基因 也被定位到亚染色体区域或特定图谱 位置沿着这些染色体通过使用经典孟德尔 十字架 这些研究导致了基因的染色体图谱 编码肿瘤排斥抗原gp 96、Fms和Met原- 癌基因和可能代表亲嗜性MuLV的序列 细胞表面受体 体细胞杂交也被 用于定位克隆探针所针对的其他染色体基因， available. 最近，我们绘制了精子细胞的基因图谱， 果蝇热休克相关蛋白、基因 蛋白质，P450细胞色素和几种T淋巴细胞抗原。