BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS

三氯乙烯(TCE)和2，6-二甲基亚胺这两种挥发性化学物质已经被 分别包裹在明胶-山梨醇微胶囊中。这些 已经证明，这些配方可以为 化学物质，以便它们可能在剂量饲料毒理学研究中有用。这个 该项目的目标是比较 整洁和微囊化化学品在大鼠和小鼠体内的吸收，以及 评估使用微胶囊作为一种手段的可行性 在啮齿动物饲料中添加不稳定的测试化学品进行毒理学研究 学习。三氯乙烯的吸收速率和吸收程度 微胶囊化三氯乙烯在玉米油中的悬浮或作为纯净的溶液 用玉米油中的TCE灌胃给雄性Fischer 344只大鼠 学习。在B6C3F1小鼠身上进行的类似研究正在进行中。毒性 正在研究微囊化三氯乙烯在大鼠和小鼠体内的作用。

Trichloroethylene (TCE) and 2,6-xylidine, two volatile chemicals, have been separately encapsulated in gelatin-sorbitol microcapsules. These formulations have been shown to provide sufficient stability to the chemicals so that they may be useful in dosed-feed toxicology studies. The objectives of this project are to compare the rates and extents of absorption of neat and microencapsulated chemicals in rats and mice, and to evaluate the feasibility of using microencapsulation as a means of incorporating unstable test chemicals into rodent feed for toxicology studies. The rates and extents of absorption of TCE, prepared either as a suspension of microencapsulated TCE in corn oil or as a solution of neat TCE in corn oil, administered by gavage to male Fischer 344 rats have been studied. Similar studies in B6C3F1 mice are being developed. The toxicity of microencapsulated TCE in rats and mice is being studied.