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BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS

BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS
微囊化学品的生物利用度和毒性研究
批准号：
4693193
负责人：
R L MELNICK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4693193
关键词：
amines drug administration routes drug vehicle gastrointestinal drug absorption gastrointestinal toxin absorption pharmacokinetics toxicant interaction toxin metabolism trichloroethylene

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中文摘要
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英文摘要
Trichloroethylene (TCE) and 2,6-xylidine, two volatile chemicals, have been separately encapsulated in gelatin-sorbitol microcapsules. These formulations have been shown to provide sufficient stability to the chemicals so that they may be useful in dosed-feed toxicology studies. The objectives of this project are to compare the rates and extents of absorption of neat and microencapsulated chemicals in rats and mice, and to evaluate the feasibility of using microencapsulation as a means of incorporating unstable test chemicals into rodent feed for toxicology studies. The rates and extents of absorption of TCE, prepared either as a suspension of microencapsulated TCE in corn oil or as a solution of neat TCE in corn oil, administered by gavage to male Fischer 344 rats have been studied. Similar studies in B6C3F1 mice are being developed. The toxicity of microencapsulated TCE in rats and mice is being studied.
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BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS
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BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS