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TOXIC EFFECTS OF 1,2-DIBROMO-3-CHLOROPROPANE ON THE UROGENITAL SYSTEM

TOXIC EFFECTS OF 1,2-DIBROMO-3-CHLOROPROPANE ON THE UROGENITAL SYSTEM
1,2-二溴-3-氯丙烷对泌尿生殖系统的毒性作用
批准号：
3965242
负责人：
R L MELNICK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3965242
关键词：
animal age group chlorohydrocarbon insecticide cytotoxicity dosage environmental contamination environmental toxicology hepatotoxin insecticide biological effect kidney function liver metabolism renal toxin reproductive system spermicide toxin metabolism urinary tract

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中文摘要
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英文摘要
The acute and subchronic toxic effects of the pesticide 1,2-dibromo-3-chloropropane (DBCP) and structurally-related compounds are studied from functional and mechanistic viewpoints. A reported chemo-sterilant in humans, DBCP is no longer manufactured in the U.S., but its presence in ground water and on edible imports and its illegal bulk transport into certain areas of the U.S. require its further toxicological characterization. Effects of DBCP on hepatic, renal, and reproductive functions and development are evaluated at several dose levels, after various treatment regimens and under differing conditions such as age, chemical or physical stress and the like. The mechanism of DBCP inhibition of energy metabolism in sperm cells is being investigated.
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