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MECHANISMS OF PHTHALATE ESTER TOXICITIES IN MAMMALIAN SPECIES

MECHANISMS OF PHTHALATE ESTER TOXICITIES IN MAMMALIAN SPECIES
哺乳动物中邻苯二甲酸酯的毒性机制
批准号：
4693183
负责人：
R L MELNICK
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4693183
关键词：
chemical carcinogenesis diethylhexylphthalate dosage environmental toxicology hepatotoxin plastics spermicide teratogens toxin metabolism zinc

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英文摘要
Phthalate esters are plasticizers incorporated into nearly all plastic materials. The biochemical and ultrastructural effects of di(2-ethylhexyl)phthalate (DEHP) and related chemicals are being studied in order to assess potential mechanisms of phthalate ester toxicity. Since DEHP and other phthalates are also male chemosterilants and teratogenic in mice, studies are being conducted to determine the role of zinc in the pathophysiology of these reproductive effects and to discern no-observed toxic effect levels.
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BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS
MECHANISM OF DI(2-ETHYLHEXYL)PHTHALATE HEPATOTOXICITY
MECHANISM OF DI(2-ETHYLHEXYL)PHTHALATE HEPATOTOXICITY
BIOAVAILABILITY AND TOXICITY STUDIES OF MICROENCAPSULATED CHEMICALS