MODELS IN THE MONKEY OF GENERALIZED SEIZURES OF THE ABSENCE TYPE

全身性癫痫发作活动伴失神电图表现 癫痫（双侧对称性和同步阵发性 每秒三次的尖峰和波放电）可以在猴子中引起 通过各种方法。 这些包括电刺激各种 大脑内的位置，注射惊厥药物和其他 物质，以及可能改变正常 细胞内的抑制机制。 创建的模型癫痫发作状态 研究这些方法是为了检验关于病理生理学的假设， 癫痫发作机制，感觉处理和注意力能力， 失神发作，棘波活动对细胞活动的影响，以及 可能改变或减少抽搐的技术或操作的效果 活动 最近，该项目涉及以下工作：我们 研究了GABA增强剂的（自相矛盾的）诱导排尿作用， 全身麻醉对听觉脑干诱发电位的影响 注射戊四氮引起的癫痫发作。

Generalized seizure activity with the electrographic appearance of absence epilepsy (bilaterally symmetrical and synchronous paroxysmal three-per-second spike and wave discharges) can be elicited in the monkey by a variety of methods. These include electrical stimulation of various locations within the brain, injection of convulsant drugs and other substances, and administration of compounds which may alter normal inhibitory mechanisms within the cell. Model seizure states created in these ways are studied in order to test hypotheses about pathophysiological seizure mechanisms, sensory processing and attentional capacities during absence seizures, effects of spike-wave activity on cellular activity, and effects of techniques or maneuvers which may modify or reduce convulsive activity. Most recently this project has involved the following work: we studied the (paradoxical) seizure-inducing effects of a GABA-enhancer and the effects on auditory brain stem evoked potentials of generalized seizures induced by injection of pentylenetetrazol.