Understanding environmental and airborne routes of transmission

了解环境和空气传播途径

• 批准号: MC_PC_19064
• 负责人: Allan Bennett
• 金额: $ 38.67万
• 依托单位: Public Health England
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_19064
• 关键词: Understanding; environmental; airborne; routes; transmission

Understanding how the causatative agent of COVID-19, SARS-CoV-2 is spread from person-to-person is essential for outbreak control. Little is known about the environmental stability of SARS-CoV-2 and establishing if/how the environment affects the survival and/or transmissibility (spread) of the virus is an immedate research priority (as identifed by the WHO Global Research and Innovation Forum). This study will determine how long SARS-CoV-2 will survive in the air and on different types of surfaces (e.g. those found in the healthcare, domestic and community setting). Methods to effectively decontaminate these surfaces will also be investigated. Techniques will also be developed in order to develop validated sampling methods for the agent in healthcare facilities. Experiments will be carried out using specialist facilities and equipment at Public Health England and will be conducted under controlled environmental conditions (e.g. at a range of temperatures and humidities) representative of those found in different countries and/or settings. This study is essential if the transmission of SARS-CoV-2 is to be fully understood. The results obtained will clarify how environmental factors can impact the spread of the virus and will inform effective (and evidence-based) strategies and guidance for preventing and controlling infection in healthcare and non-healthcare settings worldwide.

了解COVID-19的病原体SARS-CoV-2如何在人与人之间传播对于疫情控制至关重要。关于SARS-CoV-2的环境稳定性知之甚少，确定环境是否/如何影响病毒的生存和/或传播（传播）是一个迫切的研究重点（如世卫组织全球研究和创新论坛所确定的）。这项研究将确定SARS-CoV-2在空气中和不同类型的表面（例如在医疗保健，家庭和社区环境中发现的表面）上存活多久。还将研究有效净化这些表面的方法。还将开发技术，以便为医疗机构中的代理开发经验证的采样方法。实验将使用英国公共卫生部的专业设施和设备进行，并将在代表不同国家和/或环境的受控环境条件（例如，温度和湿度范围）下进行。如果要充分了解SARS-CoV-2的传播，这项研究至关重要。所获得的结果将阐明环境因素如何影响病毒的传播，并将为预防和控制全球医疗保健和非医疗保健环境中的感染提供有效的（和基于证据的）策略和指导。

项目成果

Characterisation of Particle size and Viability of SARS-CoV-2 Aerosols from a Range of Nebuliser Types Using a Novel Sampling Technique

使用新型采样技术表征一系列雾化器类型中的 SARS-CoV-2 气溶胶的粒径和活性

• DOI: 10.20944/preprints202202.0240.v1
• 发表时间: 2022
• 作者: Paton S

Detection of SARS-CoV-2 within the healthcare environment: a multi-centre study conducted during the first wave of the COVID-19 outbreak in England.

• DOI: 10.1016/j.jhin.2020.11.024
• 发表时间: 2021-03
• 期刊: The Journal of hospital infection
• 作者: Moore G;Rickard H;Stevenson D;Aranega-Bou P;Pitman J;Crook A;Davies K;Spencer A;Burton C;Easterbrook L;Love HE;Summers S;Welch SR;Wand N;Thompson KA;Pottage T;Richards KS;Dunning J;Bennett A
• 通讯作者: Bennett A

A comparison of persistence of SARS-CoV-2 variants on stainless steel.

• DOI: 10.1016/j.jhin.2021.05.015
• 发表时间: 2021-08
• 期刊: The Journal of hospital infection
• 作者: Pottage T;Garratt I;Onianwa O;Spencer A;Paton S;Verlander NQ;Dunning J;Bennett A
• 通讯作者: Bennett A

Comparison of Surface Persistence of SARS-CoV-2 Alpha and Delta Variants on Stainless Steel at 4°C and 24°C.

SARS-COV-2α和三角洲变体在4°C和24°C下的表面持久性比较。

• DOI: 10.1128/aem.00764-22
• 发表时间: 2022-07-26
• 期刊: APPLIED AND ENVIRONMENTAL MICROBIOLOGY
• 影响因子: 4.4
• 作者: Onianwa, Okechukwu;Garratt, Isobel;Carter, Jennifer;Spencer, Antony;Verlander, Neville Q.;Pottage, Thomas;Bennett, Allan M.
• 通讯作者: Bennett, Allan M.

Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virus and Viral RNA in Relation to Surface Type and Contamination Concentration.

• DOI: 10.1128/aem.00526-21
• 发表时间: 2021-06-25
• 期刊: Applied and environmental microbiology
• 影响因子: 4.4
• 作者: Paton S;Spencer A;Garratt I;Thompson KA;Dinesh I;Aranega-Bou P;Stevenson D;Clark S;Dunning J;Bennett A;Pottage T
• 通讯作者: Pottage T