Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study

人口统计学、多种发病率和遗传对心肌受累及其从 COVID-19 中恢复的影响：COVID-HEART 研究

• 批准号: MC_PC_20014
• 负责人: John Greenwood
• 金额: $ 49.38万
• 依托单位: Leeds Teaching Hospitals NHS Trust
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_20014
• 关键词: Demographic; multi; morbidity; genetic; impact

Up to 1 in 5 patients hospitalised by COVID-19 have evidence of heart muscle injury as measured from a blood test. This is associated with a high death rate. Using an MRI scan of the heart we aim to investigate how often, and in what way, the heart becomes damaged, and how the heart recovers 6 months later. We need to know how heart muscle damage and recovery is affected by age, sex, ethnicity and other medical conditions (such as diabetes, high blood pressure, heart disease and narrowing of blood vessels), as these are also known to be associated with high death rates. We also want to see if we can improve the diagnosis of viral heart damage from a simple ECG, which may save patients having invasive heart tests which can be uncomfortable, are expensive and carry a small risk of serious complications and may put healthcare staff at increased risk of exposure to COVID-19.

多达五分之一的因COVID-19住院的患者有心肌损伤的证据，这是从血液测试中测得的。这与高死亡率有关。使用心脏的MRI扫描，我们的目标是调查心脏受损的频率和方式，以及6个月后心脏如何恢复。我们需要知道年龄、性别、种族和其他医疗条件（如糖尿病、高血压、心脏病和血管狭窄）如何影响心肌损伤和恢复，因为这些也与高死亡率有关。我们还想看看我们是否可以通过简单的心电图来改善对病毒性心脏损伤的诊断，这可能会使患者免于进行侵入性心脏检查，这些检查可能会感到不舒服，价格昂贵，严重并发症的风险很小，并可能使医护人员暴露于COVID-19的风险增加。

项目成果

Strengths and limitations of meta-analyses.

荟萃分析的优点和局限性。

• DOI: 10.1093/eurheartj/ehab682
• 发表时间: 2022
• 期刊: European heart journal
• 影响因子: 39.3
• 作者: Berry C

Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART-a UK, multicentre, observational study.

• DOI: 10.1186/s12968-021-00752-1
• 发表时间: 2021-06-10
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Gorecka M;McCann GP;Berry C;Ferreira VM;Moon JC;Miller CA;Chiribiri A;Prasad S;Dweck MR;Bucciarelli-Ducci C;Dawson D;Fontana M;Macfarlane PW;McConnachie A;Neubauer S;Greenwood JP;COVID-HEART investigators
• 通讯作者: COVID-HEART investigators

Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case-control study.

• DOI: 10.1186/s12968-022-00887-9
• 发表时间: 2022-09-12
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Personalizing the Competing Risks for Thrombotic and Bleeding Events in Ischemia With Nonobstructed Coronary Arteries.

个性化无阻塞冠状动脉缺血中血栓和出血事件的竞争风险。

• DOI: 10.1016/j.jcin.2021.12.010
• 发表时间: 2022
• 期刊: JACC. Cardiovascular interventions
• 作者: Berry C

Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study.

• DOI: 10.1161/circulationaha.122.060632
• 发表时间: 2023-01-31
• 期刊: CIRCULATION
• 影响因子: 37.8
• 作者: Artico, Jessica;Shiwani, Hunain;Moon, James C.;Gorecka, Miroslawa;McCann, Gerry P.;Roditi, Giles;Morrow, Andrew;Mangion, Kenneth;Lukaschuk, Elena;Shanmuganathan, Mayooran;Miller, Christopher A.;Chiribiri, Amedeo;Prasad, Sanjay K.;Adam, Robert D.;Singh, Trisha;Bucciarelli-Ducci, Chiara;Dawson, Dana;Knight, Daniel;Fontana, Marianna;Manisty, Charlotte;Treibel, Thomas A.;Levelt, Eylem;Arnold, Ranjit;Macfarlane, Peter W.;Young, Robin;McConnachie, Alex;Neubauer, Stefan;Piechnik, Stefan K.;Davies, Rhodri H.;Ferreira, Vanessa M.;Dweck, Marc R.;Berry, Colin;Greenwood, John P.
• 通讯作者: Greenwood, John P.