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CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS

CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS
DNA/蒽环类药物相互作用的量热研究
批准号：
5204060
负责人：
C P MUDD
金额：
$0.0万
依托单位：
NATIONAL CENTER FOR RESEARCH RESOURCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5204060
关键词：
DNA anthracyclines intermolecular interaction microcalorimetry thermodynamics

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中文摘要
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英文摘要
During the course of measuring the binding enthalpies of the anthracycline drug daunomycin to DNA hosts in the 10 to 20 micromolar range (where the monomeric form predominates), we found that the experimental protocol could be simplified greatly by adding a third inlet line to the existing two inlets in each channel of the microcalorimeter. This change will allow a dual-ratio mixing scheme to be used, in which we can keep the concentration of one reagent (DNA) constant and vary the concentration of the other reagent (i.e., drug) by ratioing the other two lines.
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TEMPERATURE CONTROLLED CHAMBER FOR X-RAY DIFFRACTION SPECIMENS
  • 批准号：
    3959937
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    C P MUDD
  • 依托单位：
    DIVISION OF RESEARCH SERVICES
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CALORIMETRIC INVESTIGATION OF DNA/ANTHRACYCLINE DRUG INTERACTIONS
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