IDENTIFICATION OF GENES FOR HYPERTENSION/SALT SENSITIVITY IN AFRICAN AMERICANS

之前与Svetkey博士的合作表明 5号染色体上位于或的标记之间存在连锁的证据 在β-2肾上腺素能受体附近，这至少是负责的 部分是由于治疗后舒张压的表型变化 盐的加载和耗尽。标记的额外基因分型 推测的基因侧翼没有显示出连锁的证据， 尽管之前的发现是用方差来证实的- 连锁分析的组件法。估计 侧翼标记之间的重组分数是 在这个以女性为主的人口中， 非洲裔美国人的发病率高于其他人群的报告。估计 遗传力表明，至少有一些与盐有关的特征- 敏感性很高，这表明遗传成分可能对 暴露后血压表达的实质作用 加盐。

Previous collaborations with Dr. Svetkey suggested evidence for linkage between a marker on chromosome 5, at or near the beta-2- adrenergic receptor, that was responsible, at least in part, for the phenotypic variation of diastolic blood pressure after salt loading and depletion. Additional genotyping of markers flanking the putative locus failed to show evidence of linkage, although the previous finding was corroborated using the variance- components method of linkage analysis. The estimated recombination fractions between the flanking markers were considerably larger in this population of predominantly female African-Americans than reported in other populations. Estimates of heritability suggest that at least some of the traits related to salt- sensitivity are high, suggesting that genetic components may play a substantial role in the expression of blood pressure after exposure to salt loading.