Power to detect linkage in genomic screens using moving

使用移动技术检测基因组筛选中的连锁

• 批准号: 6555982
• 负责人: ALEXANDER F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6555982
• 关键词: clinical research; data collection methodology /evaluation; family genetics; genetic disorder diagnosis; genetic markers; genetic screening; genetic susceptibility; human data; linkage mapping; longitudinal human study; mathematical model; molecular genetics; siblings; statistics /biometry

When using linkage analysis to perform genomic screening for complex traits, regions may be identified where two-point linkage analysis produces modest p-values that, taken individually, would not be considered to be suggestive of linkage. One approach is to combine information from correlated clusters of markers into regional linkage tests. In this study, the porperties of two classes of regional linkage test statistics, based on the t-statistics from the Haseman-Elston sib-pair test, were investigated over a range of heritabilities and different markers sets. Initial results based on a simulated 10 cM map suggest that the power for a moving average of two consecutive markers was larger than individual two-point tests. Larger gains in power were observed for moving averages of 3 to 5 consectutive t-tests. A follow-up study on the stochastic properties of the p-value under the alternative hypothesis in these simulations has been completed. Two manuscripts are in preparation.

当使用连锁分析来进行复杂性状的基因组筛选时，可以鉴定两点连锁分析产生适度p值的区域，所述适度p值单独考虑不会被认为暗示连锁。一种方法是将来自相关的标记群的信息联合收割机结合到区域连锁测试中。本文以Haseman-Elston同胞对检验的t统计量为基础，研究了两类区域连锁检验统计量在不同遗传力和不同标记集上的性质。基于模拟10 cM图谱的初步结果表明，两个连续标记物的移动平均值的功效大于单个两点检验。观察到3至5个连续t检验的移动平均值在功效上有较大的增益。在这些模拟中，对备择假设下p值的随机特性进行了后续研究。两份手稿正在编写中。