POWER TO DETECT LINKAGE IN GENOMIC SCREENS USING MOVING AVERAGE TEST STATISTICS

当使用连锁分析来进行复杂性状的基因组筛选时，可以鉴定两点连锁分析产生适度p值的区域，所述适度p值单独考虑不会被认为暗示连锁。一种方法是将来自相关标记簇的信息联合收割机组合成？地区性的？测试链接。本文研究了两类区域连锁检验统计量在不同遗传力和不同标记集上的性质。第一类包括来自连续标记集的最小t值，第二类包括t统计量的移动平均值。基于10 cM图的初步结果表明，要求两个连续t检验具有显著性的最小t统计量的功效比两点检验增加。对于2至5个连续t检验值的移动平均值，观察到较大的收益。检测连锁的能力的增益范围在5%和20%之间，遗传力在30%和60%之间。一种新的特设测试proceedanalagous的秩检验也被认为是，其统计特性正在进一步研究。- 计算机模拟，G.A.S.P.，遗传计量学，连锁分析，同胞对连锁分析，区域检验统计，移动平均

When using linkage analysis to perform genomic screening for complex traits, regions may be identified where two-point linkage analysis produces modest p-values that, taken individually, would not be considered to be suggestive of linkage. One approach is to combine information from correlated clusters of markers into ?regional? tests of linkage. The properties of two classes of regional linkage test statistics were investigated over a range of heritabilities and different marker sets. The first class included minimum t values from sets of consecutive markers, the second included moving averages of the t-statistics. Initial results, based on a 10 cM map, suggest that the power for the min-t statistic, requiring that two consecutive t-tests be significant, was increased over two-point tests. Larger gains were observed for moving averages of 2 to 5 consecutive t-test values. The gains in power to detect linkage ranged between 5 and 20% for heritabilities between 30% and 60%. A novel ad hoc test proceedure analagous to a rank test was also considered, and its statistical properties are being investigated further. - computer simulation, G.A.S.P., genometrics, linkage analysis, sib-pair linkage analysis, regional test statistics, moving averges