POWER TO DETECT LINKAGE IN GENOMIC SCREENS USING MOVING AVERAGE TEST STATISTICS

使用移动平均测试统计数据检测基因组屏幕中的连锁反应

• 批准号: 6290339
• 负责人: ALEXANDER F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290339
• 关键词: linkage mapping; molecular genetics; statistics /biometry

When using linkage analysis to perform genomic screening for complex traits, regions may be identified where two-point linkage analysis produces modest p-values that, taken individually, would not be considered to be suggestive of linkage. One approach is to combine information from correlated clusters of markers into ?regional? tests of linkage. The properties of two classes of regional linkage test statistics were investigated over a range of heritabilities and different marker sets. The first class included minimum t values from sets of consecutive markers, the second included moving averages of the t-statistics. Initial results, based on a 10 cM map, suggest that the power for the min-t statistic, requiring that two consecutive t-tests be significant, was increased over two-point tests. Larger gains were observed for moving averages of 2 to 5 consecutive t-test values. The gains in power to detect linkage ranged between 5 and 20% for heritabilities between 30% and 60%. A novel ad hoc test proceedure analagous to a rank test was also considered, and its statistical properties are being investigated further. - computer simulation, G.A.S.P., genometrics, linkage analysis, sib-pair linkage analysis, regional test statistics, moving averges

当使用连锁分析对复杂性状进行基因组筛选时，可以确定两点连锁分析产生适度p值的区域，这些p值单独考虑不会被认为是连锁的暗示。一种方法是将来自相关标记簇的信息组合到“区域”中。链接的测试。研究了两类区域连锁检验统计量在不同遗传力和不同标记集上的特性。第一类包括连续标记集的最小t值，第二类包括t统计量的移动平均。基于10 cM图的初步结果表明，min-t统计量（要求连续两次t检验显著）的功率比两点检验增加。对于连续2到5个t检验值的移动平均线，观察到更大的收益。遗传力在30%到60%之间，检测连锁的能力增益在5%到20%之间。还考虑了一种类似秩检验的新颖的特别检验程序，并对其统计性质进行了进一步的研究。-计算机模拟，G.A.S.P，基因组学，连锁分析，兄弟对连锁分析，区域检验统计，移动平均