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Statistical genetic analysis of coronary artery disease

Statistical genetic analysis of coronary artery disease
冠心病的统计遗传学分析
批准号:
6681714
负责人:
ALEXANDER F WILSON
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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中文摘要
翻译
该项目的目标是在家族数据中检测候选基因的潜在功能多态性与心血管相关结果(如血压)之间的关联。数据包括来自韩国的717个观察结果(87个家系)。在分析之前,对个体和家庭识别号进行随机化,以确保机密性。后代对中亲的回归(ROMP)方法将用于测试关联并估计总体性状遗传力和归因于候选基因座的遗传力。候选基因的鉴定可能有助于阐明该人群心血管疾病的病因。
英文摘要
The goal of this project is to test for association between potentially functional polymorphisms in candidate genes and cardiovascular related outcomes, such as blood pressure, in family data. The data consist of 717 observations (87 pedigrees) from Korea. The individual and family identification numbers were randomized prior to analysis to ensure confidentiality. The Regression of Offspring on Mid-Parent (ROMP) method will be used to test for association and estimate the overall trait heritability and the heritability attributable to the candidate loci. Identification of a candidate gene may help to elucidate the etiology underlying cardiovascular disease in this population.
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SEGREGATION/LINKAGE ANALYSIS FOR HYPERTENSION
  • 批准号:
    3339900
  • 项目类别:
  • 资助金额:
    $7.65万
  • 财政年份:
    1982
  • 负责人:
    ALEXANDER F WILSON
  • 依托单位:
A STUDY OF SEGREGATION/LINKAGE ANALYSIS FOR HYPERTENSION
  • 批准号:
    3339897
  • 项目类别:
  • 资助金额:
    $7.06万
  • 财政年份:
    1982
  • 负责人:
    ALEXANDER F WILSON
  • 依托单位:
A STUDY OF SEGREGATION/LINKAGE ANALYSIS FOR HYPERTENSION
  • 批准号:
    3339899
  • 项目类别:
  • 资助金额:
    $7.35万
  • 财政年份:
    1982
  • 负责人:
    ALEXANDER F WILSON
  • 依托单位:
A STUDY OF SEGREGATION/LINKAGE ANALYSIS FOR HYPERTENSION
  • 批准号:
    3339898
  • 项目类别:
  • 资助金额:
    $7.4万
  • 财政年份:
    1982
  • 负责人:
    ALEXANDER F WILSON
  • 依托单位:
海外基金