GASP--A SOFTWARE TOOL FOR METHODOLOGIC DEVELOPMENT IN STATISTICAL GENETICS

可以通过软件工具的可用性来促进用于统计遗传分析的计算机软件的开发，所述软件工具可用于1)验证算法，2)确定经验类型I错误率，3)确定测试的威力，以及4)确定测试相对于潜在假设的失败的稳健性。基因计量分析模拟程序(G.A.S.P.)是一种软件工具，可以根据用户指定的模型生成族数据样本。可以生成性状数据和标记数据。产生的数据可以简单到随机个体的单个样本，也可以复杂到数千个大家庭的样本，这些样本的特征基于主要基因、多基因、共同兄弟关系环境和协变量成分的线性组合。-计算机模拟、遗传连锁分析、遗传分析软件、基因计量学

Development of computer software for statistical genetic analysis can be facilitated by the availability of software tools that can be used to 1) verify the algorithms, 2) determine empirical type I error rates, 3) determine the power of a test, and 4) to determine the robustness of a test with respect to failures of underlying assumptions. The Genometric Analysis Simulation Program (G.A.S.P.) is a software tool that can generate samples of family data based on user-specified models. Both trait and marker data can be generated. Data generated can be as simple as a single sample of random individuals, or as complex as thousands of samples of extended families with traits based on a linear combination of major locus, polygenic, common sibship environment and covariate components. - Computer simulation, genetic linkage analysis, genetic analysis software, genometrics