GASP--A SOFTWARE TOOL FOR METHODOLOGIC DEVELOPMENT IN STATISTICAL GENETICS

GASP——统计遗传学方法开发的软件工具

• 批准号: 6290320
• 负责人: ALEXANDER F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290320
• 关键词: computer program /software; computer simulation; computer system design /evaluation; family genetics; genetic models; human data; statistics /biometry

Development of computer software for statistical genetic analysis can be facilitated by the availability of software tools that can be used to 1) verify the algorithms, 2) determine empirical type I error rates, 3) determine the power of a test, and 4) to determine the robustness of a test with respect to failures of underlying assumptions. The Genometric Analysis Simulation Program (G.A.S.P.) is a software tool that can generate samples of family data based on user-specified models. Both trait and marker data can be generated. Data generated can be as simple as a single sample of random individuals, or as complex as thousands of samples of extended families with traits based on a linear combination of major locus, polygenic, common sibship environment and covariate components. - Computer simulation, genetic linkage analysis, genetic analysis software, genometrics

统计遗传分析的计算机软件的开发可以通过软件工具的可用性来促进，这些软件工具可用于1)验证算法，2)确定经验I型错误率，3)确定测试的能力，以及4)确定测试的鲁棒性，涉及基本假设的失败。基因分析模拟程序（G.A.S.P.）是一个软件工具，可以根据用户指定的模型生成家庭数据样本。性状和标记数据都可以生成。生成的数据可以简单到随机个体的单个样本，也可以复杂到数千个大家庭的样本，这些样本的特征基于主要位点、多基因、共同兄弟姐妹环境和协变量成分的线性组合。-计算机模拟，遗传连锁分析，遗传分析软件，基因组学