MODEL-FREE SIB-PAIR LINKAGE ANALYSIS COMBINING FULL-SIB AND HALF-SIB PAIRS

当对全同胞进行连锁研究时，半同胞通常是可用的。本文提出了一种将全同胞和半同胞对的信息综合到一个连锁检验中的联合收割机方法。该方法是基于Haseman和Elston方法回归的平方性状差异的一对同胞（无论是全同胞或半同胞）的估计比例的等位基因共享相同的血统。一个校正因子，考虑了同胞之间的相关性，提出近似的分布的检验统计量，模拟被用来证明，近似在许多情况下工作良好，虽然有一些情况下，统计可以有一个膨胀的I型错误。- 计算机模拟，G.A.S.P.，遗传学，同胞对连锁分析，半同胞

When sampling full-sibs for linkage studies, half-sibs are often available. A theoretical method is proposed to combine the information from full-sib and half-sib pairs into a single test for linkage. The method is based on the Haseman and Elston method of regressing the squared trait-difference for a pair of sibs (either full- or half-sibs) on the estimated proportion of alleles shared identical by descent. A correction factor that consideres the correlation among sibs is proposed to approximate the distribution of the test statistic; simulations are used to demonstrate that the approximation works well in many situations, although there are some situations for which the statistic can have an inflated type-I error. - computer simulation, G.A.S.P., genometrics, sib-pair linkage analysis, half-sibs