GENETICS OF OBESITY IN THE AMISH

阿米什人肥胖的遗传学

• 批准号: 6290315
• 负责人: ALEXANDER F WILSON
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290315
• 关键词: Mennonite; autosomal dominant trait; child (0-11); clinical research; family genetics; gene expression; genetic markers; genotype; human subject; linkage mapping; obesity; phenotype

Information on a measure related to obesity was obtained on over 3000 Amish individuals. Segregation analysis has been done on the trait with the best fitting model being an autosomal dominant model adjusted for age and sex effects. The model has been used to identify 20 families that are informative for linkage analysis. Additional phenotyping of obesity related traits has been funded by the German Government. Genotyping is currently being done at the Center for Inherited Disease Research. Markers will be used in an attempt to identify genetic components for traits related to obesity in the Amish. - obesity, Old- Order Amish, linkage analysis, genomic screening - Human Subjects

对3000多名阿米什人进行了与肥胖有关的测量。对该性状进行了分离分析，最佳拟合模型为常染色体显性模型，并考虑了年龄和性别的影响。该模型已被用于识别20个家庭，为连锁分析提供信息。德国政府资助了肥胖相关特征的其他表型分析。基因分型目前正在遗传疾病研究中心进行。标记将被用于鉴定与阿米什人肥胖有关的基因成分。-肥胖，旧秩序阿米什人，连锁分析，基因组筛选-人类受试者