Statistical genetic analysis of asthma-related traits

本项目旨在分离分析切萨皮克湾一个孤立渔村的血清总IgE水平（tIgE）；丹吉尔岛，弗吉尼亚州。在一个完整的确定方案下，70%的人群的表型数据是可用的，所有个体都连接在一个可追溯到1722年的单一复杂谱系中。分析包括：1)tIgE的分离分析，仅利用有限的家谱数据进行分离分析是可行的；2)利用这些有限的家谱信息对数量性状的分离分析的影响。分离分析的初步结果将在2002年10月举行的美国人类遗传学学会年会上公布。正在准备提交两份手稿。

This project is aimed at the segregation analysis of total serum IgE levels (tIgE) in an isolated fishing village in the Chesapeake Bay; Tangier Island, VA. Under a complete ascertainment scheme, phenotype data are available on 70% of the population with all individuals connected in a single complex pedigree dating back to 1722. Analyses include: 1) the segregation analysis of tIgE, for which use of only restricted genealogical data is feasible; and 2) the impact of utilizing this restricted genealogical information in a segregation analysis of a quantitative trait. Preliminary results of the segregation analysis will be presented at the annual American Society of Human Genetics meeting in October 2002. Two manuscripts are in preparation for submission.