Mental Health and Circadian Science Network

心理健康和昼夜节律科学网络

• 批准号: MR/X009726/1
• 负责人: Daniel Smith
• 金额: $ 80.86万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX009726%2F1
• 关键词: Mental; Health; Circadian; Science; Network

We will establish the Mental Health and Circadian Science Network, a new collaboration between researchers, clinicians, patients and the public that will be focused on driving discovery and innovation at the interface of sleep, circadian rhythms and mental health. We will integrate research and clinical expertise to create a new network that will identify priority areas for research and launch interdisciplinary collaborations.Daily (circadian) rhythms are a fundamental feature of all life on earth, from plants to humans. These 24-hour rhythms exist at multiple molecular and cellular levels and allow organisms to align their physiology and behaviours to daily cycles of light and dark. Well-synchronized circadian rhythms are fundamental for human health and are particularly important for mental health. For example, the correct timing of exposure to light is critical for synchronizing circadian rhythms (such as the daily sleep/activity cycle) but patterns of modern living - such as shift-working and excess artificial light at night - cause desynchronization of rhythms and result in a wide range of adverse mental and physical health outcomes. This is particularly important for young people, who may be more sensitive to light-induced circadian dysfunction and associated mental health problems.In recent decades, public health initiatives have successfully focused on diet, smoking/alcohol and exercise, but the importance of healthy rhythms of sleep and activity has been relatively neglected by the research community. Similarly, even though mental health disorders such as depression, bipolar disorder and psychosis have long been known to be associated with abnormal rhythms of sleep/activity, the mechanisms of these associations are poorly understood and the clinical application of discoveries in chronobiology to mental health has so far been limited.In consultation with the research and clinical communities (and based on feedback and advice from patients and the public), we have identified four core areas of activity for the network, including: a) Setting the research agenda for mental health and circadian science; b) Setting standards for data collection, data curation and data sharing; c) Supporting Early Career Researchers (ECRs) working at the intersection of mental health and circadian science; and d) Building sustainability and new interdisciplinary grant applications.For all these activities, The McPin Foundation will establish a Patient and Public Involvement (PPI) group to provide strategic input and advice, making sure that the work is relevant to the needs of the public, clinical groups and the research community.Our goals are very well suited to a partnership grant. The UK has major research strengths in mental health, chronobiology, data science and sleep/circadian science but these activities are not currently well connected: we need to add value to these strengths by bringing together a diverse group of researchers, clinicians, patients and the public to maximize productivity and deliver long-term impact in the chronopsychiatry field.

我们将建立心理健康和昼夜节律科学网络，这是研究人员，临床医生，患者和公众之间的新合作，将专注于在睡眠，昼夜节律和心理健康的界面上推动发现和创新。我们将整合研究和临床专业知识，以创建一个新的网络，该网络将确定研究和启动跨学科合作的优先领域。每日（昼夜节律）节奏是地球上所有生命的基本特征，从植物到人类。这些24小时的节奏存在于多个分子和细胞水平上，使生物体可以将其生理和行为与光和黑暗的每日周期保持一致。合成的昼夜节律对人类健康至关重要，对心理健康尤为重要。例如，正确接触光的时间对于同步昼夜节律（例如每日睡眠/活动周期）而言至关重要，但是现代生活的模式（例如夜间的班次工作和过多的人造光）会导致节奏的脱节，并导致多种不良的心理和身体健康范围。对于年轻人来说，这尤其重要，他们可能对光引起的昼夜节律功能障碍和相关的心理健康问题更敏感。在近几十年以来，公共卫生倡议成功地专注于饮食，吸烟/酒精和运动，但健康的睡眠节奏和活动的重要性已被研究界相对忽略了。 Similarly, even though mental health disorders such as depression, bipolar disorder and psychosis have long been known to be associated with abnormal rhythms of sleep/activity, the mechanisms of these associations are poorly understood and the clinical application of discoveries in chronobiology to mental health has so far been limited.In consultation with the research and clinical communities (and based on feedback and advice from patients and the public), we have identified four core areas of activity for the network,包括：a）设定心理健康和昼夜科学的研究议程； b）设定数据收集，数据策展和数据共享的标准； c）支持早期职业研究人员（ECRS）在心理健康与昼夜科学的交集中工作； d）建立可持续性和新的跨学科赠款应用程序。对于所有这些活动，McPin基金会将建立一个患者和公众参与（PPI）小组，以提供战略意见和建议，确保工作与公众，临床团体和研究社区的需求相关。您的目标非常适合合作伙伴赠款。英国在心理健康，计时生物学，数据科学和睡眠/昼夜科学方面具有重要的研究优势，但是这些活动目前尚未良好联系：我们需要通过将一群多样化的研究人员，临床医生，患者和公众汇集在一起​​来为这些优势增加价值，以最大程度地提高生产力并在时间上的精神野外产生长期影响。

项目成果

Keep It Simple: Using README Files to Advance Standardization in Chronobiology.

• DOI: 10.3390/clockssleep5030033
• 发表时间: 2023-08-30
• 期刊: Clocks & sleep
• 影响因子: 3.1