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EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS

EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS
通过二氧化碳呼气试验评价药物代谢状态
批准号：
3822962
负责人：
E A LANE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3822962
关键词：
acetamides alcoholic beverage consumption alcoholism /alcohol abuse breath tests carbon dioxide drug metabolism gastrointestinal drug absorption human subject liver metabolism mass spectrometry methylation toxin metabolism

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英文摘要
The total disposition in man of methacetin, a drug used in the carbon dioxide breath test has been investigated. Plasma and urine concentrations of methacetin and its metabolites, acetaminophen, acetaminophen glucoronide and acetaminophen sulfate were measured by high performance liquid chromatography. The 13C-carbon dioxide in expired breath was measured by isotope ratio mass spectrometry. The fraction of the methacetin dose demthylated was calculated according to clearance concepts and also from measurement of urinary metabolites after a single dose each of methacin and acetaminophen. It was found that 100% of the methacin dose was demethylated to acetaminophen, but only 51% of the methyl carbon atoms were eliminated in breath as carbon dioxide.
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APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS
ACETYLATION PHENOTYPE OF ALCOHOLICS
APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
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