EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS

通过二氧化碳呼气试验评价药物代谢状态

• 批准号: 4687724
• 负责人: E A LANE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687724
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; breath tests; carbon dioxide; drug metabolism; gastrointestinal drug absorption; human subject; liver metabolism; mass spectrometry; methylation; toxin metabolism

The theoretical relationship of drug pharmacokinetics and carbon dioxide breath test results has been investigated, using the well-stirred model of liver metabolism. The effects of hepatic extraction ratio, fraction metabolized by demethylation, and absorption rate of drug upon breath test results were simulated, using the MLAB package on the DEC 10 computer. It was demonstrated that a drug suitable for detecting changes in drug-metabolizing status via the carbon dioxide breath test should be at least 50% metabolized by demethylation, should have an hepatic extraction ratio of 0.2 to 0.5, and should be administered orally in a form that is rapidly absorbed.

药物动力学与二氧化碳的理论关系 呼吸试验结果进行了研究，使用搅拌良好的模型， 肝脏代谢 肝提取率、提取分数 通过去甲基化代谢，呼吸试验时药物的吸收率 使用DEC 10计算机上的MLAB软件包模拟结果。 它 证明了一种适用于检测 通过二氧化碳呼吸试验的药物代谢状态应在 至少50%通过去甲基化代谢，应进行肝脏提取 比例为0.2至0.5，并且应该以 迅速吸收。