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EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS

EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS
通过二氧化碳呼气试验评价药物代谢状态
批准号：
4687724
负责人：
E A LANE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4687724
关键词：
alcoholic beverage consumption alcoholism /alcohol abuse breath tests carbon dioxide drug metabolism gastrointestinal drug absorption human subject liver metabolism mass spectrometry methylation toxin metabolism

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英文摘要
The theoretical relationship of drug pharmacokinetics and carbon dioxide breath test results has been investigated, using the well-stirred model of liver metabolism. The effects of hepatic extraction ratio, fraction metabolized by demethylation, and absorption rate of drug upon breath test results were simulated, using the MLAB package on the DEC 10 computer. It was demonstrated that a drug suitable for detecting changes in drug-metabolizing status via the carbon dioxide breath test should be at least 50% metabolized by demethylation, should have an hepatic extraction ratio of 0.2 to 0.5, and should be administered orally in a form that is rapidly absorbed.
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APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
ACETYLATION PHENOTYPE OF ALCOHOLICS
EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS
APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION