Dissecting the role of NOD-like receptors (NLRs) in Helicobacter pylori disease

剖析 NOD 样受体 (NLR) 在幽门螺杆菌疾病中的作用

• 批准号: nhmrc : 1079904
• 负责人: A/Pr Richard Ferrero
• 金额: $ 42.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-nod-pylori-disease/518709
• 关键词: Dissecting; role; NOD; like; receptors

Half of the world's 6.5 billion people harbour the bacterium Helicobacter pylori in their stomachs. Approximately 1% of these infections develop into gastric cancer, representing the second leading cause of cancer-related death world-wide. This research project will investigate the role of a family of host defence proteins as mediators of inflammatory and cell survival responses which contribute to the development of gastric cancer disease.

世界上65亿人中有一半人的胃中含有幽门螺杆菌。这些感染中约有1%发展为胃癌，是全球癌症相关死亡的第二大原因。本研究计划将探讨一个宿主防御蛋白家族作为炎症和细胞存活反应介质的作用，这些反应有助于胃癌疾病的发展。