Helicobacter pylori acquisition of host cholesterol: its role in inflammation

幽门螺杆菌获取宿主胆固醇：其在炎症中的作用

• 批准号: nhmrc : 1030243
• 负责人: A/Pr Richard Ferrero
• 金额: $ 27.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/helicobacter-pylori-acquisition-role-inflammation/110743
• 关键词: Helicobacter; pylori; acquisition; host; cholesterol

The bacterium Helicobacter pylori is present in the stomach of half the world’s population. It is estimated that 20% of these people will suffer from peptic ulcer disease, whereas as many as 1% will develop stomach cancer later in life. The common factor in all these diseases is the inflammation induced by the bacterium. This project will investigate a new mechanism by which H. pylori causes inflammation and how dietary cholesterol may be involved in this process.

幽门螺杆菌存在于世界上一半人口的胃中。据估计，这些人中有20%会患上消化性溃疡，而多达1%的人会在晚年患上胃癌。所有这些疾病的共同因素是由细菌引起的炎症。本项目将探讨H.幽门螺杆菌引起炎症以及饮食中的胆固醇如何参与这一过程。