The impact of virulence gene polymorphisms on Helicobacter pylori pathogenesis.

毒力基因多态性对幽门螺杆菌发病机制的影响。

• 批准号: nhmrc : 1006010
• 负责人: A/Pr Richard Ferrero
• 金额: $ 29.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-virulence-gene-pylori-pathogenesis/109134
• 关键词: impact; virulence; gene; polymorphisms; Helicobacter

The bacterium Helicobacter pylori causes various types of disease of the stomach and intestine. It is still not clear, however, why some infected individuals develop very severe forms of disease (ulcers or cancer) whilst others develop only inflammation. This project will investigate H. pylori interactions with cells that line the stomach wall and how these interactions may contribute to the development of more severe disease.

幽门螺杆菌会引起各种胃肠道疾病。然而，目前还不清楚为什么一些感染者会发展成非常严重的疾病(溃疡或癌症)，而另一些人只会发展成炎症。这个项目将研究幽门螺杆菌与胃壁细胞的相互作用，以及这些相互作用如何有助于更严重的疾病的发展。