NOD1 sensing of H. pylori peptidoglycan promotes cell survival and bacterial persistence

NOD1 感应幽门螺杆菌肽聚糖可促进细胞存活和细菌持久性

• 批准号: nhmrc : 1079930
• 负责人: A/Pr Richard Ferrero
• 金额: $ 52.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nod1-sensing-h-bacterial-persistence/518712
• 关键词: NOD1; sensing; H.; pylori; peptidoglycan

The bacterium H. pylori lives in the stomach of half the world’s population and is a major cause of human disease, including peptic ulcers and stomach cancer. This project will investigate how H. pylori is able to manipulate the host immune system by modifying the composition of its outside layer (the cell wall). In so doing, H. pylori causes changes in cells of the stomach lining that allow the bacterium to persist, but that also may predispose the host to cancer.

细菌H.幽门螺杆菌存在于世界一半人口的胃中，是导致消化性溃疡和胃癌等人类疾病的主要原因。本课题将研究H.幽门螺杆菌能够通过改变其外层（细胞壁）的组成来操纵宿主免疫系统。这样做，H。幽门螺旋杆菌引起胃粘膜细胞的变化，使细菌得以持续存在，但这也可能使宿主容易患上癌症。