NLRC5, a new regulator of Helicobacter-induced inflammation

NLRC5，螺杆菌引起的炎症的新调节因子

• 批准号: nhmrc : 1107930
• 负责人: A/Pr Richard Ferrero
• 金额: $ 44.01万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nlrc5-new-regulator-induced-inflammation/663009
• 关键词: NLRC5; new; regulator; Helicobacter; induced

Helicobacter pylori lives in the stomach of half the world’s population and is a major cause of human disease, including cancer. The body fights H. pylori infection by mobilising white blood cells to the stomach lining, resulting in inflammation. We have evidence that H. pylori can attenuate this inflammation by targeting a host protein, NLRC5. This project will determine the role of NLRC5 in preventing inflammation and cancer due to H. pylori infection.

幽门螺杆菌生活在世界上一半人口的胃中，是人类疾病的主要原因，包括癌症。身体对抗H。幽门螺杆菌感染通过动员白色血细胞到胃粘膜，导致炎症。我们有证据表明H。幽门螺杆菌可以通过靶向宿主蛋白NLRC 5来减轻这种炎症。该项目将确定NLRC 5在预防H.幽门感染