Bacterial outer membrane vesicles as immunomodulatory agents in Helicobacter pylori infection

细菌外膜囊泡作为幽门螺杆菌感染的免疫调节剂

• 批准号: nhmrc : 519518
• 负责人: A/Pr Richard Ferrero
• 金额: $ 20.44万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bacterial-outer-membrane-pylori-infection/95459
• 关键词: Bacterial; outer; membrane; vesicles; immunomodulatory

Chronic inflammation of the stomach is a hallmark of Helicobacter pylori infection, and is a precursor to peptic ulcer disease and cancer. Like many other bacteria, H. pylori sheds spherical blebs from its surface. These blebs bind to stomach cells in vitro and have been found in stomach biopsies of H. pylori-infected subjects. The aims of the work are to investigate the mechanisms whereby H. pylori blebs enter and disseminate within host cells, and how this may contribute to inflammation.

胃的慢性炎症是幽门螺杆菌感染的标志，并且是消化性溃疡疾病和癌症的前兆。像许多其他细菌一样，H。幽门从其表面脱落球形泡。这些水泡在体外与胃细胞结合，并在H.幽门感染者本工作的目的是探讨H.幽门疱疹进入并在宿主细胞内传播，以及这如何导致炎症。